How Does Cialis Work

CialisĀ® (Tadalafil) works by inhibiting PDE5. Phosphodiesterase type 5 (PDE5) is an phosphodiesterase enzyme found in many bodily tissues, and most importantly it’s found in corpus cavernosum. PDE5 is responsible for breaking down the cGMP (Cyclic GMP). cGMP is very important in achieving an erection. Thus, stopping the PDE5, causes the release of Cyclic GMP – which is actually the main function of Cialis (Tadalafil).

Compared to https://www.edsante.net/a-propos-du-cialis.html and similar PDE5 inhibitors, Cialis (Tadalafil) has much longer life. Tadalafil has a life of up to 36 hours, while Viagra and Levitra are about 8-10 hours.

Cialis results in much longer male erection. This is why Cialis is also called “The Weekend Pill”. Tadalafil is also used in treatment of pulmonary arterial hypertension.

Penile erection is achieved by increased blood circulation to the corpus cavernosum. Corpus Cavernosum are two chambers in the penile tissue. They are filled with a spongy tissue. When those spongy tissues are filled with blood, they inflate the penis and cause an erection.

In order to blood flow get into the Corpus Cavernosum, its smooth muscles and arteries must be relaxed. When you’re sexually stimulated, brain sends signals to the nerves to release the nitric oxide. That stimulates the production of Cyclic GMP (cGMP). cGMP is directly responsible for relaxation of corpus cavernosum’s muscles.

As we mentioned before, PDE5 enzyme actually breaks down the cGMP, thus stopping the entering of blood into the penis. Inhibition of PDE5 increases the production amount of cGMP and enhances the penis erection. This is how Cialis (Tadalafil) works – it inhibits the PDE5 thus helping the blood flow to enter the Corpus Cavernosum. When the inhibition of PDE5 stops, blood again has difficulties to enter the penis. That’s why it is so important that erectile dysfunction treatment lasts longer. Keep in mind that Cialis works up to 3 times longer than similar PDE5 inhibitors!

Proper sexual stimulation is needed for successful penis erection. Only when you’re excited, brain sends signals to release the nitric oxide and cGMP. When you take daily dosages of Cialis, you also achieve better self-confidence. By better self-esteem you help your brain to relax the penile muscles. The best cure for impotence is relaxed mind, appropriate sexual stimulation and additional help of CialisĀ® (Tadalafil)!

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